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New Microscopy Approach can Make the Smallest Objects Clearly Visible Without Fluorescence

When cities transform into a colorful world of lights as darkness falls, it's often only possible to estimate their contours, which depending on the perspective can draw the attention to key details or trivia.

15 Apr 2022

New Method for Better Visualizing Fibroblasts in the Central Nervous System

The central nervous system (CNS) consists of several types of cells having varied specialized functions. While many of these cell types have been studied, fibroblast cells in the CNS remain underexplored.

7 Apr 2022

Miniature Microscope Designed for High-Resolution 3D Images Inside Mouse Brains

Researchers have developed a miniature microscope that is designed for high-resolution 3D images inside the brains of living mice. By imaging deeper into the brain than previously possible with miniature widefield microscopes, the new lightweight microscope could help scientists better understand how brain cells and circuits operate.

30 Mar 2022

AI and Ghost Imaging Enhances Super-Resolution Imaging

Super-resolution methods based on frequency shift can boost the resolution of microscope images by two times. STORM, STED, and other methods in fluorescence microscopy can boost spatial resolution to more than 10 times the diffraction limit, and the latter received the Nobel Prize in Chemistry in 2014.

25 Mar 2022

Two-Photon MINFLUX Pushes the Boundaries of Achievable Resolution in Optical Nanoscopes

While many researchers use optical nanoscopes for their research, they are currently limited in their resolution due to how light diffracts. While techniques have been developed to combat this, there are still improvements. One research team in Beijing believes that multi-photon microscopy is the answer.

25 Mar 2022

PSI Researchers Develop an Innovative Achromatic Lens for X-Rays

PSI scientists have developed a ground-breaking achromatic lens for X-rays. This allows the X-ray beams to be accurately focused on a single point even if they have different wavelengths.

15 Mar 2022

New Method Enables Rapid 3D Image Acquisition

A newly proposed technique enables rapid 3D image acquisition. One-scan is a technique involving an elongated light spot that resembles a "needle" which captures three-dimensional (3D) images of a specimen.

9 Mar 2022

New Microscope System Uses Short-Wave Infrared Light to Illuminate Blood, Bacteria

Inflammation of the middle ear is often triggered a cholesteatoma, an aggressive form of chronic otitis media. In order to detect cholesteatomas and bacterial biofilms and to remove them safely, the new collaborative project 'BetterView' is working on a special surgical microscope.

8 Mar 2022

New Lensless Microscopy Captures Cellular-Level Details in Living Tissue

First, catch the tiger. Then attach Bio-FlatScope, the latest iteration of lensless microscopy being developed at Rice University.

8 Mar 2022

Microscope Reveals the Optical Properties of Living Cone Mitochondria Exposed to Light

Researchers at the National Eye Institute (NEI) have discovered that power-producing organelles in the eye's photoreceptor cells, called mitochondria, function as microlenses that help channel light to these cells' outer segments where it's converted into nerve signals.

8 Mar 2022