Feb 16 2010
Malvern Instruments will focus on its range of analytical instrumentation for life science applications, with an emphasis on the company’s comprehensive solutions for characterizing proteins and other macromolecules. Today Malvern offers a variety of options, with a range of systems that can be configured to meet the analysis requirements of individual laboratories. These include the Zetasizer family, which employs dynamic and static light scattering to measure size and molecular weight, and the full range of Viscotek advanced gel permeation / size exclusion chromatography (GPC/SEC) systems and detectors for rapid, reliable characterization of both molecular weight and molecular structure.
In addition to the established and widely used Zetasizer Nano system, Malvern’s Zetasizer family now includes a system dedicated to the analysis of proteins and other biomolecules. Designed and optimised for maximum sensitivity and minimum sample volume, the Zetasizer Micro V is a dedicated system that supports improved understanding and management of a wide range of biomolecule applications. These include: optimising sample and storage conditions; verifying the quaternary structure of protein complexes; identifying thermal characteristics; and assessing protein solubility and sample purity.
When it comes to GPC/SEC, Malvern provides a wide choice for chemists seeking either a complete system or an additional detector to enhance an existing set-up. At the heart of the company’s chromatography range are Viscotek advanced GPC/SEC systems. These include the powerful yet easy to use TDAmax, which can be configured with up to four detectors to deliver maximum information from a single experiment. Light scattering, viscosity, concentration, refractive index and UV detection are all available on the TDAmax. The system delivers information on absolute molecular weight without correction or extrapolation, oligomeric composition and aggregation, protein size and density, conjugate composition and second virial coefficient. OmniSEC software not only offers standard methodologies for instrument control, analysis and customised reporting, it can also deal with specialised applications, such as the analysis of pegylated proteins.